Ameloblastoma is a slow growing, and locally aggressive tumor with high recurrence rates. The tumor can assume large sizes. It arises from epithelium of the dental lamina. Clinically the tumor can presents itself as swelling which are generally asymptomatic. Histologically there are many variants. Radiographically the tumor can occur either as mutilocular radioluscent lesion giving a peculiar honey comb appearance or as a unicystic variety. There are many treatment options available which range from conservative treatment of curettage, enucleation to radical surgical approaches of wide margin excision. Radical treatment approaches have the advantage of lowering the recurrence rates but at the same time pose extremely difficult challenges of reconstruction of the surgical defects. We are reporting a case of a 20 year old young female diagnosed with a large multicystic ameloblastoma of the mandible in which wide margin surgical excision of the tumor by segmental resection of the left hemimandible was performed with spanning of the boney defect with titanium reconstruction plates to achieve a favorable aesthetic and functional outcome for the patient.
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